January 18, 2000Circulation
Contrasting Inotropic Effects of Endogenous Endothelin in the Normal and Failing Human Heart
Why the study?
Does BQ123 infusion alter myocardial contractile function differently in normal subjects versus patients with dilated cardiomyopathy?
Population
16 patients undergoing diagnostic catheterization, comprising 8 with atypical chest pain and 8 with…
Comparison
BQ123 (ET receptor antagonist) infused into the… vs Baseline measurements and comparison between…
Design
Other
Follow-up
16 minutes
Authors
Discussion
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Member takes
Implication
Suggests loss of ET-1 inotropic support in DCM; hypothesis-generating for targeted endothelin therapies.
Structured PICO
Does BQ123 infusion alter myocardial contractile function differently in normal subjects versus patients with dilated cardiomyopathy?
P
Population
16 patients undergoing diagnostic catheterization, comprising 8 with atypical chest pain (normal left ventricular function and coronary arteries) and 8 with nonischemic dilated cardiomyopathy (DCM).
I
Intervention
BQ123 (ET(A) receptor antagonist) infused into the left coronary artery at 40 nmol/min for 16 minutes.
C
Comparator
Baseline measurements (pre-infusion) and comparison between normal subjects and DCM patients.
O
Outcome
Change in LV dP/dt(max) and LV dP/dt at a developed pressure of 40 mm Hg (LV dP/dt(40)) after 16 minutes.surrogate
Endogenous ET-1 exerts a tonic positive inotropic effect in normal human hearts, but this effect is lost or potentially reversed in patients with nonischemic dilated cardiomyopathy.
Cite This Study
MacCarthy et al. (2000) studied this question.