Why the study?
Does high-dose doxorubicin compared to low-dose doxorubicin affect cardiopulmonary status and exercise capacity in survivors of acute lymphoblastic leukemia?
Population
19 patients evaluated 1.1 to 7.1 years after successful treatment of acute lymphoblastic leukemia with Dana…
Comparison
High cumulative doses of doxorubicin for high or… vs Low cumulative doses of doxorubicin for standard…
Design
Cross-sectional
Follow-up
mean 4.6 +/- 1.5 years after treatment
Authors
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Associated with reduced LV function and adiposity in higher-risk survivors; hypothesis-generating for dose effects on cardiopulmonary outcomes.
Does high-dose doxorubicin compared to low-dose doxorubicin affect cardiopulmonary status and exercise capacity in survivors of acute lymphoblastic leukemia?
Survivors of acute lymphoblastic leukemia treated with higher doses of doxorubicin exhibit subtle reductions in left ventricular systolic function and increased body fat compared to those receiving lower doses or healthy controls.
Turner-Gomes et al. (1996) studied this question.
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