Higher pulse pressure is independently associated with higher TNF-α and neutrophil count in elderly women, suggesting a link between pulse pressure, inflammation, and insulin resistance.
Answers are grounded in this paper and cite their sources.
Pulse pressure links to TNF-α and neutrophils in elderly women; hypothesis-generating for inflammation in vascular risk and requires longitudinal confirmation.
AIMS: Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension. METHODS: Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women, 79 women (52.7%) of whom had hypertension. RESULTS: Systolic blood pressure (standardized β, 0.775), log tumor necrosis factor-α (TNF-α, standardized β, 0.110), age (standardized β, 0.140), and neutrophil count (standardized β, 0.114) emerged as determinants of PP independent of high-sensitivity C-reactive protein, interleukin-6, monocyte count, plasminogen activator inhibitor-1, homeostasis model assessment of insulin resistance, HDL-cholesterol, and adiponectin (R(2) = 0.772). CONCLUSIONS: The present studies have demonstrated an independent association of higher PP with higher TNF-α, a marker of insulin resistance, and neutrophil count in community-living elderly women and suggest that insulin resistance and chronic low-grade inflammation may in part be responsible for the association between high PP and incident type 2 diabetes found in elderly patients with hypertension.
No takes yet. Share an insight, caveat, or question.
Yamada et al. (2014) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: