Why the study?
Does abnormal thyroid function in potential cardiac allograft donors predict graft function or failure?
Does abnormal thyroid function in potential cardiac allograft donors predict graft function or failure?
Abnormal thyroid function in cardiac allograft donors prior to cardiectomy does not appear to correlate with subsequent graft function or failure.
Abnormal donor thyroid function need not alter acceptance decisions; leaves open prospective validation of thyroid screening in transplantation.
Twenty-two potential cardiac allograft donors had evaluation of thyroid function performed just prior to cardiectomy. Despite statistically significant abnormal thyroid function, no correlation to graft function or failure was observable. Multiple myocardial microinfarcts, undetected at the time of donor selection were detected in two hearts that were abandoned prior to transplantation and possibly another heart that failed as an allograft in a heart-lung transplant recipient.
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Macoviak et al. (1987) studied this question.
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