What question did this study set out to answer?

To establish an efficient palladium(II)-catalyzed protocol for the directed borylation of primary and secondary C(sp3)–H bonds using a promoting ligand.

November 27, 2015Angewandte Chemie International EditionOpen Access

Ligand‐Promoted Borylation of C(sp³)H Bonds with Palladium(II) Catalysts

View Full Paper

Ask AI

Bookmark

To establish an efficient palladium(II)-catalyzed protocol for the directed borylation of primary and secondary C(sp3)–H bonds using a promoting ligand.
Applied a quinoline-based ligand paired with a palladium(II) catalyst to direct C(sp3)–H bond functionalization.
Evaluated substrate scope across primary β-C(sp3)–H bonds of carboxylic acid derivatives and secondary positions within three- to seven-membered carbocyclic rings.
Facilitated selective borylation of primary β-C(sp3)–H positions in carboxylic acid derivatives.
Achieved directed secondary C(sp3)–H borylation across cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes, and cycloheptanes.
Expanded reaction scope and mild operational conditions complementary to traditional iridium(I)- and rhodium(I)-catalyzed borylation systems.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Experimental study demonstrates ligand-promoted borylation across diverse carbocycles and carboxylic acid derivatives, highlighting a versatile palladium alternative to iridium catalysis.

Cite This Study

He et al. (2015) studied this question.

synapsesocial.com/papers/6a70a06a2163a0a01bc4d879 https://doi.org/10.1002/anie.201509996

View Full Paper

Ask AI

Bookmark

Implication

Experimental study demonstrates ligand-promoted borylation across diverse carbocycles and carboxylic acid derivatives, highlighting a versatile palladium alternative to iridium catalysis.

Ligand‐Promoted Borylation of C(sp³)H Bonds with Palladium(II) Catalysts

Key Points

Discussion

Implication

Cite This Study

Ligand‐Promoted Borylation of C(sp³)H Bonds with Palladium(II) Catalysts

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider