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October 4, 2023European Heart Journal

Sex-specific characteristics and outcomes in hospitalized heart failure with preserved ejection fraction: the China Cardiovascular Association Database-Heart Failure Center Registry

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Why the study?

Sex differences in HFpEF characteristics and outcomes are documented, but whether these differences vary by LVEF was unclear.

Does female sex compared to male sex affect the risk of adverse outcomes in hospitalized HFpEF patients?

Population

51 711 hospitalized HFpEF patients across 575 hospitals in mainland China

Comparison

Female vs male patients across three LVEF groups

Design

Nationwide multicentre registry study

Follow-up

1-year

Authors

ACAnping CaiWQWeida QiuSXShuang Xia

Discussion

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Member takes

Overview

Sex differences in hospitalized HFpEF outcomes may vary by LVEF; leaves open LVEF-stratified sex-specific risk models.

Structured PICO

Does female sex compared to male sex affect the risk of adverse outcomes in hospitalized HFpEF patients?

P
Population
51,711 hospitalized patients with heart failure with preserved ejection fraction (HFpEF, LVEF ≥50%) from 575 secondary and tertiary hospitals in mainland China.
I
Intervention
Female sex
C
Comparator
Male sex
O
Outcome
Composite of hospitalization for heart failure (HHF) or cardiovascular death at 1-year follow-upcomposite

Among hospitalized HFpEF patients, women have a higher adjusted risk for adverse outcomes at 1 year compared to men, and this association does not vary by LVEF.

Limitations

  • Possibility of residual confounding
  • Lack of data on management during index admission and at follow-up
  • Events were not adjudicated

Cite This Study

Cai et al. (2023) studied this question.

synapsesocial.com/papers/6a70a2eee36a167817e27490https://doi.org/10.1093/eurheartj/ehad619
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical characteristics and 1‐year outcomes in hospitalized patients with heart failure with preserved ejection fraction: results from the China Cardiovascular Association <scp>Database‐Heart</scp> Failure Center Registry2022 · 55 citations
  2. 2Characteristics of Heart Failure With Preserved Ejection Fraction Across the Range of Left Ventricular Ejection Fraction2022 · 149 citations
  3. 3Interactions Between Left Ventricular Ejection Fraction, Sex and Effect of Neurohumoral Modulators in Heart Failure2020 · 93 citations
  4. 4Sex differences in heart failure2019 · 814 citations
  5. 5Genetic and phenotypic profiling of supranormal ejection fraction reveals decreased survival and underdiagnosed heart failure2022 · 48 citations