Population
Human heart sodium channels
Comparison
Substitution of tyrosine residues Y1494 and… vs Wild-type human heart sodium channels
Design
Preclinical
Authors
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Informs NaV1.5 gating research in models; leaves open relevance to human arrhythmias or therapies.
Tyrosine residues Y1494 and Y1495 in human heart sodium channels are required for normal coupling between activation voltage sensors and the inactivation gate.
O’Leary et al. (1995) studied this question.
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