Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 15, 1996The Journal of PhysiologyOpen Access

Coupling between fast and slow inactivation revealed by analysis of a point mutation (F1304Q) in mu 1 rat skeletal muscle sodium channels.

View Full Paper
Ask AI
Bookmark
Share

Population

Xenopus laevis oocytes expressing wild-type and F1304Q mutant mu 1 rat skeletal muscle Na+ channels

Comparison

F1304Q mutation in the cytoplasmic loop between… vs Wild-type mu 1 rat skeletal muscle Na+ channels

Design

Preclinical

Authors

HNHanne NussNational Institute on AgingJBJeffrey R. BalserVanderbilt UniversityDODavid W. OriasTampa General Hospital

Discussion

Loading...

Member takes

Implication

Indicates shared determinants of fast and slow Na-channel inactivation; leaves open translation to mammalian or human models.

Structured PICO

P
Population
Xenopus laevis oocytes expressing wild-type and F1304Q mutant mu 1 rat skeletal muscle Na+ channels
I
Intervention
F1304Q mutation in the cytoplasmic loop between the third and fourth domains (III-IV linker)
C
Comparator
Wild-type mu 1 rat skeletal muscle Na+ channels
O
Outcome
Whole-cell and single-channel currents and inactivation kineticssurrogate

The F1304Q mutation in mu 1 sodium channels modifies both fast and slow inactivation simultaneously, suggesting these processes share physical determinants.

Cite This Study

Nuss et al. (1996) studied this question.

synapsesocial.com/papers/6a70a2fbe36a167817e274d5https://doi.org/10.1113/jphysiol.1996.sp021502
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of III-IV linker mutations on human heart Na+ channel inactivation gating.1994 · 142 citations
  2. 2A mutation in segment IVS6 disrupts fast inactivation of sodium channels.1994 · 123 citations
  3. 3Sodium channel inactivation from resting states in guinea‐pig ventricular myocytes.1991 · 51 citations
  4. 4Molecular Localization of an Ion-Binding Site Within the Pore of Mammalian Sodium Channels1992 · 278 citations
  5. 5Genotype-Phenotype Correlations in Human Skeletal Muscle Sodium Channel Diseases1993 · 91 citations