Supernormal excitability as a mechanism of chaotic dynamics of activation in cardiac Purkinje fibers.
Population
Isolated sheep cardiac Purkinje fibers (2-5 mm in length)
Comparison
Decreasing potassium chloride concentration of… vs Normal preparations (7 mM potassium chloride)
Design
Preclinical
Authors
Discussion
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Implication
Implicates supernormal excitability in chaotic Purkinje rhythms; hypothesis-generating for clinical arrhythmia mechanisms.
Structured PICO
P
Population
Isolated sheep cardiac Purkinje fibers (2-5 mm in length)
I
Intervention
Decreasing potassium chloride concentration of Tyrode's solution from 7 to 4 mM and repetitive stimulation with depolarizing current pulses
C
Comparator
Normal preparations (7 mM potassium chloride)
O
Outcome
Excitability recovery function, restitution of the action potential duration, and response patternssurrogate
Supernormal excitability and the slope of action potential duration restitution at short diastolic intervals are responsible for the development of chaotic dynamics and complex rhythms in cardiac Purkinje fibers.
Cite This Study
Chialvo et al. (1990) studied this question.