What question did this study set out to answer?

September 9, 2003Hypertension

Individual Blood Pressure Responses to Changes in Salt Intake

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Why the study?

Does varying dietary sodium intake produce consistent individual systolic blood pressure responses in adults?

Key Points

To assess the variability and consistency of individual systolic blood pressure responses to changes in dietary salt intake.
Randomized trial in 188 participants who consumed identical diets at higher (140 mmol/d), medium (104 mmol/d), and lower (62 mmol/d) sodium levels for 30 days each in random order following a 2-week run-in period at the higher sodium level.
Evaluated individual systolic blood pressure changes across sodium phases as well as changes across repeated exposures to identical sodium intake to determine response consistency via Spearman correlation.
Systolic blood pressure change from run-in to the higher sodium period (no dietary change) ranged from -24 to +25 mm Hg, with 8.0% of participants decreasing by ≥10 mm Hg.
Comparing higher to lower sodium intake (78-mmol difference), systolic blood pressure change ranged from -32 to +17 mm Hg, with 33.5% of participants experiencing a reduction of ≥10 mm Hg.
Individual blood pressure responses exhibited low-order consistency across dietary transitions (combined Spearman r=0.27, P=0.002).

Structured PICO

Does varying dietary sodium intake produce consistent individual systolic blood pressure responses in adults?

Population

188 participants

Intervention

Dietary sodium intake at higher (140 mmol/d), medium (104 mmol/d), and lower (62 mmol/d) levels for 30 days each, in random order, after 2 weeks of run-in at the higher sodium level

Comparator

Different sodium intake levels compared within the same individuals

Outcome

Variability and consistency of individual systolic blood pressure responses to changes in salt intakesurrogate

Individual blood pressure responses to sodium reduction are highly variable and inconsistent, supporting population-wide rather than targeted sodium reduction strategies.

Discussion

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Implication

Individual SBP responses to sodium intake are inconsistent; challenges personalized strategies and supports population-wide reduction.

Cite This Study

Obarzanek et al. (2003) studied this question.

synapsesocial.com/papers/6a70ac31e36a167817e27fd7 https://doi.org/10.1161/01.hyp.0000091267.39066.72

Topics

Hypertension management

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Individual Blood Pressure Responses to Changes in Salt Intake

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Individual Blood Pressure Responses to Changes in Salt Intake

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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