The study proposes a model of smooth-muscle cell contraction where the contractile apparatus extends between closely spaced attachment sites on the cell membrane.
Does not alter clinical vascular management; extends in vitro models of smooth-muscle contraction for future research.
The contraction of isolated smooth-muscle cells has been correlated with evagination of the cell membrane, a marked change in myofilament orientation, and a decrease in cellular volume. Both localized and full contractions have been elicited in the same cell by varying the intensity of electrical stimulation. These results may be explained by a model of the smooth-muscle cell in which the contractile apparatus extends between attachment sites on the cell membrane that are relatively closely spaced.
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Fay et al. (1973) studied this question.
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