March 1, 1979Angiology
Decreased Venous Distensibility in Essential Hypertension: Lack of Systemic Hemodynamic Correlates
Why the study?
Are forearm venous distensibility and capillary filtration rate altered in male patients with essential hypertension compared to normotensive controls?
Population
48 males, comprising 27 patients with essential hypertension and 21 normotensive control subjects.
Design
Case-control
Authors
Discussion
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Implication
Supports microvascular changes in hypertension independent of systemic hemodynamics; leaves open pathophysiologic and therapeutic implications.
Key Points
- To determine whether forearm venous distensibility and capillary filtration rate are altered in essential hypertension and whether these changes correlate with systemic hemodynamic indices.
- Evaluated 27 male patients with essential hypertension and 21 normotensive male control subjects.
- Measured forearm venous distensibility and capillary filtration rate at 30 cm H2O distending pressure using strain gauge plethysmography.
- Assessed systemic parameters including plasma renin activity, plasma volume via Evans blue dye dilution, mean arterial pressure via cuff, and cardiac output via carbon dioxide rebreathing.
- Forearm venous distensibility was significantly decreased (P < 0.05) and venous pressure-volume deflation curves were shifted toward the pressure axis (P < 0.02) in hypertensive subjects compared to controls.
- Capillary filtration rate was significantly higher in hypertensive patients than in normotensive controls (P < 0.05).
- Venous distensibility alterations showed no significant correlation with plasma renin activity, mean arterial pressure, plasma volume, cardiac output, stroke volume, or total peripheral resistance.
Structured PICO
Are forearm venous distensibility and capillary filtration rate altered in male patients with essential hypertension compared to normotensive controls?
P
Population
48 males, comprising 27 patients with essential hypertension and 21 normotensive control subjects.
C
Comparator
Normotensive control subjects
O
Outcome
Forearm venous distensibility and capillary filtration rate at 30 cm of H2O distending pressuresurrogate
The study confirms decreased venous distensibility and increased capillary filtration in essential hypertension, though these changes do not correlate with systemic hemodynamics, leaving their pathophysiologic role unclear.
Cite This Study
Simon et al. (1979) studied this question.