Why the study?
Does chrono-therapy with different dosing schedules of diltiazem improve circadian blood pressure profiles in patients with essential hypertension?
Does chrono-therapy with different dosing schedules of diltiazem improve circadian blood pressure profiles in patients with essential hypertension?
Evening administration of sustained-release diltiazem is more efficacious than morning or thrice-daily dosing in controlling circadian blood pressure profiles, particularly the morning surge, in essential hypertension.
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Evening dosing was associated with better morning BP control; hypothesis-generating for chrono-therapy, requiring RCTs before practice change.
Kohno et al. (1996) studied this question.
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