June 10, 1988JAMA
Characterization of Antihypertensive Therapy by Whole-Day Blood Pressure Monitoring
Why the study?
Does diltiazem reduce whole-day blood pressure in patients with clinically diagnosed hypertension compared to placebo?
Population
Patients with clinically diagnosed hypertension.
Comparison
Diltiazem hydrochloride vs Placebo
Design
Other
Authors
Discussion
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Member takes
Implication
Requires ambulatory confirmation of hypertension before diltiazem; challenges office-based diagnosis in both practice and trials.
Structured PICO
Does diltiazem reduce whole-day blood pressure in patients with clinically diagnosed hypertension compared to placebo?
P
Population
Patients with clinically diagnosed hypertension (n=15 in the diltiazem treatment arm, subdivided into n=9 with confirmed hypertension [24-hour average diastolic blood pressure ≥ 90 mm Hg] and n=6 unconfirmed).
I
Intervention
Diltiazem hydrochloride
C
Comparator
Placebo
O
Outcome
Change in systolic and diastolic blood pressure measured by conventional sphygmomanometer and whole-day automated monitoringsurrogate
Whole-day ambulatory blood pressure monitoring effectively identifies true hypertension and documents the true efficacy of antihypertensive therapy.
Cite This Study
Michael A. Weber (1988) studied this question.