Population
Human umbilical vein endothelial cells (HUVECs)
Design
Preclinical
Authors
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Endothelial M6P receptor prorenin uptake likely clears ligand rather than enabling local angiotensin generation; leaves open in vivo vascular RAS contributions.
M6P receptor-mediated prorenin internalization by endothelial cells likely represents a clearance mechanism rather than contributing to local angiotensin generation.
Eijnden et al. (2001) studied this question.
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