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August 1, 1999Anti-Cancer Drugs

Comparative cardiotoxicity of idarubicin and doxorubicin using the isolated perfused rat heart model

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Why the study?

Does idarubicin have lower cardiotoxicity compared to doxorubicin in an isolated perfused rat heart model?

Population

Isolated perfused rat heart model

Comparison

Idarubicin administered i.v. every other day for… vs Doxorubicin administered i.v. every other day…

Design

Preclinical

Follow-up

11 days

Authors

DPDenis PlatelCentre National de la Recherche ScientifiquePPPaul PounaInstitut BergoniéSBSimone Bonoron‐AdèleInserm

Discussion

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Implication

Supports lower idarubicin cardiotoxicity in rat hearts; hypothesis-generating for human anthracycline selection.

Structured PICO

Does idarubicin have lower cardiotoxicity compared to doxorubicin in an isolated perfused rat heart model?

P
Population
Isolated perfused rat heart model
I
Intervention
Idarubicin administered i.v. every other day for 11 days at doses of 0.5, 0.75 and 1 mg/kg per injection
C
Comparator
Doxorubicin administered i.v. every other day for 11 days at doses of 1, 2, 2.5 and 3 mg/kg per injection
O
Outcome
Cardiac effects (developed pressure, contractility and relaxation of the left ventricle) and cardiotoxicitysafety

In an isolated perfused rat heart model, idarubicin demonstrated significantly lower cardiotoxicity and cardiac accumulation compared to doxorubicin at maximum tolerated doses.

Cite This Study

Platel et al. (1999) studied this question.

synapsesocial.com/papers/6a70d01826a7f98052dd44b5https://doi.org/10.1097/00001813-199908000-00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development of the model of rat isolated perfused heart for the evaluation of anthracycline cardiotoxicity and its circumvention1996 · 62 citations
  2. 2Comparation of animal models of acute toxicity of doxorubicin2025
  3. 3Preclinical evaluation of the cardiac toxicity of HMR-1826, a novel prodrug of doxorubicin1999 · 21 citations
  4. 4Antiarrhythmic effect of amiodarone on doxorubicin acute toxicity in working rat hearts1990 · 12 citations
  5. 5Cardiac safety of aldoxorubicin compared to doxorubicin: Integrated results from two randomized studies in advanced soft tissue sarcoma.2026