Population
HeLa cells, cell lines, tissues permissive for poliovirus infection, and CD44-expressing mouse L-cell…
Design
Preclinical
Authors
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AF3 inhibition of poliovirus does not implicate CD44 as receptor; leaves open noncovalent or signaling interactions in animal models.
The monoclonal antibody AF3, which inhibits poliovirus binding, recognizes the lymphocyte homing receptor CD44, though CD44 itself is not the poliovirus receptor.
Shepley et al. (1994) studied this question.
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