Why the study?
Does captopril or hydralazine alter the cardiac β-adrenoceptor pathway in rats with chronic myocardial infarction?
Does captopril or hydralazine alter the cardiac β-adrenoceptor pathway in rats with chronic myocardial infarction?
In a rat model of chronic heart failure, captopril improves G-protein activity without altering β-adrenoceptor density, distinguishing its mechanism from hydralazine.
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Distinguishes captopril from hydralazine on post-MI β-adrenergic signaling in rats; hypothesis-generating for differential HF mechanisms.
Hitoshi Adachi (1992) studied this question.
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