Witness to Progress
Why the study?
Does modern heart failure therapy improve survival compared to historical therapy in outpatients with mild-moderate heart failure?
Population
Outpatients referred for predominantly NYHA class II heart failure, mean ejection fraction 0.30, excluding…
Comparison
Recent era heart failure therapy vs Historical era heart failure therapy
Design
Editorial
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
Modern heart failure therapy, particularly increased beta-blocker use, is associated with significantly improved 1-year survival in outpatients with mild-to-moderate heart failure.
Structured PICO
Does modern heart failure therapy improve survival compared to historical therapy in outpatients with mild-moderate heart failure?
P
Population
Outpatients referred for predominantly NYHA class II heart failure, mean ejection fraction 0.30, excluding atrial fibrillation and diabetes.
I
Intervention
Recent era heart failure therapy (including broader use of aldosterone antagonists and almost 10-fold increase in beta-blockers)
C
Comparator
Historical era heart failure therapy
O
Outcome
1-year mortality ratehard clinical
Modern heart failure therapy, particularly increased beta-blocker use, is associated with significantly improved 1-year survival in outpatients with mild-to-moderate heart failure.
Limitations
- Excluded atrial fibrillation and diabetes, which affect approximately one-third of patients with heart failure and are generally associated with higher mortality rates.
Cite This Study
Stevenson et al. (2011) studied this question.