What question did this study set out to answer?

To compare changes in plasma renin activity and hemodynamic responses induced by vasodilators between normal conscious dogs and dogs with impaired cardiac reserve.

August 1, 1983European Journal of Clinical Investigation

Changes in plasma renin activity and haemodynamics during vasodilator therapy in conscious dogs with myocardial infarction or chronic volume overload

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Why the study?

Does vasodilator therapy alter plasma renin activity and hemodynamics in conscious dogs with myocardial infarction or chronic volume overload?

Population

Conscious dogs, including normal dogs, dogs with an aortocaval fistula created 4 weeks earlier, and dogs…

Comparison

Vasodilator therapy: 60-minute nitroprusside… vs Normal dogs and baseline values.

Design

Preclinical

Follow-up

Up to 1 week

Authors

HPH. PouleurMcMaster University RERobert L. EnglerGeneral Cardiology JLJoseph LinkUniversity of California, San Diego

Discussion

Member takes

Implication

May attenuate vasodilator benefits via renin activation and volume retention in canine HF models; leaves open translation to patients.

Key Points

To compare changes in plasma renin activity and hemodynamic responses induced by vasodilators between normal conscious dogs and dogs with impaired cardiac reserve.
Assessed conscious normal dogs, dogs with chronic volume overload caused by an aortocaval fistula created 4 weeks prior (n=5), and dogs with prior myocardial infarction (n=5).
Administered a 60-minute nitroprusside infusion across all groups and evaluated acute and 1-week effects of daily hydralazine in dogs with myocardial infarction.
In normal dogs, nitroprusside increased plasma renin activity from 1.05 ± 0.26 to 8.35 ± 1.20 ng AI/ml/h (P < 0.002) and heart rate from 83 ± 6 to 149 ± 15 beats/min (P < 0.002).
In dogs with an aortocaval fistula, nitroprusside produced a blunted renin increase (0.90 ± 0.29 to 4.44 ± 0.64 ng/ml/h; P < 0.01) with unchanged heart rate (134 ± 4 to 139 ± 7 beats/min; NS), a pattern also observed in dogs with myocardial infarction (heart rate: 108 to 107 beats/min; NS).
Hydralazine acutely increased plasma renin activity in post-infarction dogs from 1.05 ± 0.26 to 8.99 ± 0.79 ng AI/ml/h (P < 0.05); after 1 week, plasma volume increased from 54.9 ± 0.9 to 74.5 ± 4.9 ml/kg (P < 0.05) while renin remained elevated at 4.66 ± 0.66 ng/ml/h (P < 0.01).

Structured PICO

Does vasodilator therapy alter plasma renin activity and hemodynamics in conscious dogs with myocardial infarction or chronic volume overload?

Population

Conscious dogs, including normal dogs, dogs with an aortocaval fistula created 4 weeks earlier (n=5), and dogs with a previous myocardial infarction (n=5).

Intervention

Vasodilator therapy: 60-minute nitroprusside infusion or hydralazine administration (acute and for 1 week).

Comparator

Normal dogs (for disease models) and baseline values (pre-infusion).

Outcome

Changes in plasma renin activity and heart rate.surrogate

Vasodilator therapy rapidly activates vasoconstrictor forces and fluid retention in canine models of heart disease, which may limit its beneficial hemodynamic effects.

Cite This Study

Pouleur et al. (1983) studied this question.

synapsesocial.com/papers/6a70e3d8f44fa9f079dea14e https://doi.org/10.1111/j.1365-2362.1983.tb00109.x

Topics

Heart failure HFrEF treatment

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Changes in plasma renin activity and haemodynamics during vasodilator therapy in conscious dogs with myocardial infarction or chronic volume overload

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Changes in plasma renin activity and haemodynamics during vasodilator therapy in conscious dogs with myocardial infarction or chronic volume overload

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider