Why the study?
Does electrical stimulation of sympathetic cardiac nerves trigger coronary t-PA release in anesthetized pigs?
Population
Anesthetized pigs studied in an open chest model with bilateral vagotomy
Comparison
Electrical stimulation of sympathetic cardiac… vs Alternative interventions to test mechanisms…
Design
Preclinical
Authors
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Sympathetic stimulation markedly increases coronary t-PA release in pigs; hypothesis-generating for autonomic modulation of fibrinolysis in humans.
Does electrical stimulation of sympathetic cardiac nerves trigger coronary t-PA release in anesthetized pigs?
Stimulation of cardiac sympathetic nerves induces a marked coronary release of t-PA in a porcine model, a response partially mediated by beta-adrenergic receptors.
Björkman et al. (2003) studied this question.
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