Why the study?
Does sternotomy induce acute coronary release of tissue-type plasminogen activator in pigs?
Population
Anaesthetised pigs (n=16)
Comparison
Sternotomy (surgical stimulation) vs Before sternotomy (control)
Design
Preclinical
Follow-up
10 minutes
Authors
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Supports endothelial promotion of local fibrinolysis during porcine sternotomy; leaves open translation to human perioperative hemostasis.
Does sternotomy induce acute coronary release of tissue-type plasminogen activator in pigs?
Surgical stress from sternotomy induces a rapid, transient release of t-PA in the coronary circulation, suggesting the endothelium actively promotes local endogenous fibrinolysis during surgery.
Österlund et al. (2000) studied this question.
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