Why the study?
Does regional myocardial ischemia induce regulated release of t-PA in the coronary vasculature in vivo?
Population
Healthy anesthetized (pentobarbital) pigs (n=8)
Comparison
10-min left anterior descending region coronary… vs Baseline (before occlusion)
Design
Preclinical
Follow-up
10 minutes of reflow
Authors
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Animal evidence links myocardial ischemia to rapid coronary t-PA release; leaves open its role in human endogenous fibrinolysis.
Does regional myocardial ischemia induce regulated release of t-PA in the coronary vasculature in vivo?
Myocardial ischemia induces a rapid, local release of t-PA in the coronary vasculature, suggesting an endogenous profibrinolytic defense mechanism against thrombosis.
Österlund et al. (2002) studied this question.
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