Key result
Coronary artery disease was associated with a considerably reduced coronary net release of total and active t-PA during sternotomy compared to patients without the disease.
Why the study?
Does coronary artery disease reduce the acute release of t-PA into the coronary circulation during major surgery?
Population
22 patients undergoing the initial phase of heart surgery, comprising 14 with coronary artery disease and 8…
Comparison
Noxious stimuli and pre-surgery atrial pacing. vs Patients without coronary artery disease (n=8).
Design
Cohort
Authors
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CAD may heighten perioperative thrombosis risk via impaired fibrinolysis; hypothesis-generating for targeted interventions.
Observational (n=22)
Does coronary artery disease reduce the acute release of t-PA into the coronary circulation during major surgery?
Patients with coronary artery disease exhibit deficient local endothelial t-PA release during major surgery, suggesting a reduced fibrinolytic capacity that may explain their increased risk for perioperative coronary thrombosis.
Österlund et al. (2008) conducted an observational in Coronary artery disease (n=22). Coronary artery disease vs. Without coronary artery disease was evaluated on Coronary net release of total and active t-PA during sternotomy. Coronary artery disease was associated with a considerably reduced coronary net release of total and active t-PA during sternotomy compared to patients without the disease.
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