March 1, 1997The Anatomical RecordOpen Access

Weibel-Palade bodies as a storage site of calcitonin gene-related peptide and endothelin-1 in blood vessels of the rat carotid body

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Population

Adult male rats

Design

Preclinical

Authors

TOTakatoshi Ozaka YDYoshiaki DoiChugai Pharma (United States)KKKotaro KayashimaTokai University

Discussion

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Implication

Provides ultrastructural basis for local peptide-mediated vascular control in carotid body; leaves open translation beyond rodent models.

Structured PICO

Population

Adult male rats

Intervention

Light and electron microscope immunocytochemistry for calcitonin gene-related peptide (CGRP) and endothelin-1 (ET-1)

Outcome

Localization of CGRP and ET-1 in the vasculature of the carotid bodysurrogate

CGRP and ET-1 are synthesized and stored in the Weibel-Palade bodies of endothelial cells in the rat carotid body, suggesting a role in the autoregulation of blood flow.

Cite This Study

Ozaka et al. (1997) studied this question.

synapsesocial.com/papers/6a70ea5ba7fbea1e44084104 https://doi.org/10.1002/(sici)1097-0185(199703)247:3<388::aid-ar10>3.0.co;2-l

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Weibel-Palade bodies as a storage site of calcitonin gene-related peptide and endothelin-1 in blood vessels of the rat carotid body

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Weibel-Palade bodies as a storage site of calcitonin gene-related peptide and endothelin-1 in blood vessels of the rat carotid body

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider