Why the study?
Do standard clot-based assays (PT, aPTT, dilute PT) accurately estimate rivaroxaban concentrations in clinical samples?
Population
127 inpatient samples for rivaroxaban concentration measurement
Comparison
Prothrombin time, activated partial… vs HPLC-MS/MS assay and calibrated anti-Xa assay
Design
Cross-sectional
Authors
Loading...
Clot-based assays correlate poorly with rivaroxaban levels; leaves open their utility for clinical decision-making.
Do standard clot-based assays (PT, aPTT, dilute PT) accurately estimate rivaroxaban concentrations in clinical samples?
Standard clot-based assays like PT and aPTT have poor correlation with actual rivaroxaban levels and lack the sensitivity needed for clinical decision-making regarding safe drug concentrations.
Thöm et al. (2018) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: