Key result
Biophen DiXaI showed high linear correlation with LC-MS/MS for measuring rivaroxaban concentrations (r² = 0.95), whereas PT methods correlated poorly (r² ≈ 0.60).
Why the study?
Do chromogenic anti-Xa assays and PT tests accurately estimate rivaroxaban plasma concentrations compared to LC-MS/MS in patients treated with rivaroxaban?
Population
52 plasma samples from patients treated with rivaroxaban
Comparison
Biophen Direct Factor Xa Inhibitor® chromogenic… vs Liquid chromatography-tandem mass spectrometry
Authors
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Biophen DiXaI may reliably quantify rivaroxaban >30 ng/ml; leaves open outcome impact versus LC-MS/MS before routine adoption.
Observational (n=52)
Do chromogenic anti-Xa assays and PT tests accurately estimate rivaroxaban plasma concentrations compared to LC-MS/MS in patients treated with rivaroxaban?
Effect estimate: r² = 0.95
The Biophen DiXaI chromogenic anti-Xa assay is a reliable method for estimating rivaroxaban concentrations >30 ng/ml, whereas PT tests are inaccurate and should not be used for this purpose.
Tamigniau et al. (2013) conducted an observational in Patients treated with rivaroxaban (n=52). Biophen DiXaI (chromogenic anti-Xa assay) and PT tests vs. LC-MS/MS was evaluated on Linear correlation with LC-MS/MS for rivaroxaban concentrations (r² = 0.95). Biophen DiXaI showed high linear correlation with LC-MS/MS for measuring rivaroxaban concentrations (r² = 0.95), whereas PT methods correlated poorly (r² ≈ 0.60).
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