Why the study?
Does estimated glomerular filtration rate significantly affect plasma concentrations of B-type natriuretic peptides in elderly individuals with suspected heart failure?
Population
474 elderly outpatients with suspected heart failure (prevalence 13%) from primary care
Design
Cross-sectional
Authors
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Modest eGFR-natriuretic peptide association persists after adjustment; leaves open whether renal function meaningfully confounds diagnosis in elderly suspected HF.
Does estimated glomerular filtration rate significantly affect plasma concentrations of B-type natriuretic peptides in elderly individuals with suspected heart failure?
The effect of eGFR on proBNP and BNP concentrations is modest and substantially reduced after adjusting for clinical and echocardiographic confounders, suggesting renal function alone does not fully explain elevated natriuretic peptide levels.
Schou et al. (2009) studied this question.
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