Why the study?
What are the population pharmacokinetic parameters of intravenous amiodarone and which demographic covariates affect them?
Population
Patients of various ages and with various degrees of renal function and left ventricular function from three…
Design
Other
Authors
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Amiodarone PK modeling may proceed without renal or EF adjustments; leaves open prospective validation for dosing applications.
What are the population pharmacokinetic parameters of intravenous amiodarone and which demographic covariates affect them?
Population pharmacokinetic analysis of intravenous amiodarone using NONMEM validates two-stage analysis results, showing a four-compartment model best describes its disposition without significant influence from renal or left ventricular function.
Vadiei et al. (1997) studied this question.
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