Why the study?
Does the dose and duration of amiodarone administration affect its disposition kinetics in male Sprague-Dawley rats?
Population
Male Sprague-Dawley rats
Comparison
30 mg kg-1 intravenous bolus of 14C-amiodarone… vs 30 mg kg-1 intravenous bolus of 14C-amiodarone…
Design
Preclinical
Follow-up
48 hours
Authors
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Amiodarone alters its own disposition in rats; leaves open human pharmacokinetic interactions and dosing implications.
Does the dose and duration of amiodarone administration affect its disposition kinetics in male Sprague-Dawley rats?
Amiodarone clearance and steady-state volume of distribution are dose-dependent but independent of the duration of drug administration in a rat model.
Weir et al. (1987) studied this question.
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