Key result
Amiodarone exhibited a mean elimination half-life of 7.2 hours after a single oral dose and 29 days after discontinuation of maintenance therapy.
Population
Patients with ventricular tachyarrhythmias.
Design
Cohort
Follow-up
up to several weeks
Authors
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Requires caution with interactions long after stopping; extends single-dose PK data to chronic arrhythmia therapy.
Amiodarone exhibits a very long elimination half-life (mean 29 days) after long-term maintenance therapy, consistent with its prolonged therapeutic effect in treating cardiac arrhythmias.
Kannan et al. (1982) studied Ventricular tachyarrhythmias (n=22). Amiodarone was evaluated on Amiodarone serum kinetics (elimination rate constant and half-life). Amiodarone exhibited a mean elimination half-life of 7.2 hours after a single oral dose and 29 days after discontinuation of maintenance therapy.
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