Why the study?
Does long-term oral amiodarone therapy result in predictable cardiac concentrations based on plasma levels?
Population
Patients receiving long-term oral amiodarone therapy
Design
Other
Follow-up
long-term
Authors
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Plasma monitoring may aid amiodarone dosing; hypothesis-generating and requires prospective validation before practice change.
Does long-term oral amiodarone therapy result in predictable cardiac concentrations based on plasma levels?
There is a linear relationship between plasma and cardiac concentrations of amiodarone during long-term therapy, allowing prediction of cardiac levels from routine blood analysis.
Debbas et al. (1983) studied this question.
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