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March 1, 1982Journal of Cardiovascular Pharmacology

Pharmacokinetics of Amiodarone in Man

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Why the study?

What are the pharmacokinetic properties of oral and intravenous amiodarone in healthy volunteers and patients with supraventricular tachycardia?

Population

9 individuals (3 healthy volunteers and 6 patients with supraventricular tachycardia)

Design

Other

Follow-up

Up to 50 hours

Authors

EREmma RivaBioengineering Technology and Systems (Italy)MGM. GernaNerviano Medical SciencesRLRoberto LatiniHeart Failure & Transplant

Discussion

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Implication

Supports monitoring amid variable bioavailability; extends PK data in SVT patients but leaves optimal regimens open.

Structured PICO

What are the pharmacokinetic properties of oral and intravenous amiodarone in healthy volunteers and patients with supraventricular tachycardia?

P
Population
9 individuals (3 healthy volunteers and 6 patients with supraventricular tachycardia)
I
Intervention
Amiodarone administered as single oral (400 mg) and intravenous (150 mg or 5 mg/kg) doses, with some patients receiving subsequent oral therapy (200 mg/day)
O
Outcome
Pharmacokinetic parameters including volume of distribution, elimination half-life, and systemic bioavailabilitysurrogate

Amiodarone has a large volume of distribution, a long elimination half-life, and highly variable oral bioavailability, which informs its clinical dosing strategy.

Cite This Study

Riva et al. (1982) studied this question.

synapsesocial.com/papers/6a712b2945e51b8c20274cbfhttps://doi.org/10.1097/00005344-198203000-00015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Amiodarone kinetics after oral doses1982 · 128 citations
  2. 2Amiodarone pharmacokinetics. II. Disposition kinetics following subchronic administration in rat1987 · 4 citations
  3. 3Clinical pharmacokinetics and efficacy of amiodarone for refractory tachyarrhythmias.1983 · 242 citations
  4. 4Population pharmacokinetics of long-term oral amiodarone therapy2000 · 102 citations
  5. 5Population Pharmacokinetics of Intravenous Amiodarone and Comparison with Two‐Stage Pharmacokinetic Analysis1997 · 23 citations