Characterizes the structure and expression of env gene products in a subset of thymotropic dual-tropic murine leukemia viruses.
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Env expression patterns in murine leukemia isolates are largely conserved; leaves open relevance to human retroviral disease.
The env gene products of nine AKR dual-tropic murine leukemia viruses were compared by peptide mapping and were assayed for expression on the cell surface of infected fibroblasts. Seven virus isolates expressed the env gene polyprotein on the cell surface. The env gene products of six of the seven viruses had identical peptide maps. The analysis of structure and expression of env gene products carried out in this study characterizes a subset of dual-tropic murine leukemia viruses shown by others to be thymotropic.
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Famulari et al. (1981) studied this question.
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