Why the study?
Does long-term insulin injection induce atherosclerosis-like lesions in male Wistar rats?
Population
50 male Wistar rats
Comparison
Daily injection of insulin-zinc suspension for 1… vs Daily injection of saline for 1 year
Design
Preclinical
Follow-up
1 year
Authors
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May implicate insulin in rat aortic lesions; leaves open relevance to human diabetic macroangiopathy.
Does long-term insulin injection induce atherosclerosis-like lesions in male Wistar rats?
Long-term hyperinsulinism induces atherosclerosis-like lesions in the aortas of rats, suggesting a role in the development of diabetic macroangiopathy.
Sato et al. (1989) studied this question.
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