Key result
Insulin protects against T2DM-induced aortic damage and vascular inflammation in preclinical models.
Why the study?
The protective effect of insulin against T2DM-induced ultrastructural damage to the aortic tunica intima and media had not been investigated using transmission electron microscopy.
Does insulin prevent aortic ultrastructural damage and improve vascular injury biomarkers in a rat model of T2DM?
Population
Rats with T2DM induced by high fat diet and streptozotocin (50 mg/kg)
Comparison
Daily i.v. insulin vs untreated T2DM control
Design
Controlled animal experiment
Follow-up
8 weeks
Authors
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Hypothesis-generating for insulin's vascular protection in T2DM models; leaves open human translation.
Does insulin prevent aortic ultrastructural damage and improve vascular injury biomarkers in a rat model of T2DM?
p-value: p=< .05
Insulin treatment for 8 weeks in a T2DM rat model protects against aortic ultrastructural damage and reduces biomarkers of vascular inflammation and oxidative stress.
Alzamil et al. (2020) studied Type 2 diabetes mellitus. Insulin vs. Untreated T2DM control group was evaluated on Aortic ultrastructural damage and blood levels of biomarkers of vascular injury, inflammation, and oxidative stress (p=< .05). Insulin treatment for 8 weeks substantially protected against T2DM-induced aortic ultrastructural damage and significantly inhibited up-regulation of inflammatory and vascular injury biomarkers (p<0.05).
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