Key result
Insulin treatment in rats with type 1 diabetes mellitus substantially protected against aortopathy, resulting in 85% normal aortic endothelial cell morphology and significantly reducing biomarkers of vascular injury.
Why the study?
The study sought to investigate the protective effect of insulin against type 1 diabetes mellitus-induced aortic injury associated with the inhibition of biomarkers of vascular injury.
Does insulin prevent aortopathy and reduce biomarkers of vascular injury in a rat model of type 1 diabetes mellitus?
Population
Rats with streptozotocin-induced type 1 diabetes mellitus
Comparison
Insulin treatment vs diabetic and control conditions
Design
Animal experimental study
Follow-up
8 weeks
Authors
Loading...
Insulin's aortic protection in diabetic rats does not alter clinical practice; leaves open translation to human type 1 diabetes vasculopathy.
Does insulin prevent aortopathy and reduce biomarkers of vascular injury in a rat model of type 1 diabetes mellitus?
Absolute Event Rate: 85% vs 15%
In a rat model of type 1 diabetes, insulin treatment protects against diabetic aortopathy and reduces biomarkers of vascular injury, inflammation, and oxidative stress.
Bin‐Jaliah et al. (2019) studied Type 1 diabetes mellitus-induced aortopathy (n=18). Insulin vs. Untreated type 1 diabetes mellitus was evaluated on Aortic endothelial cell morphology (percent normal). Insulin treatment in rats with type 1 diabetes mellitus substantially protected against aortopathy, resulting in 85% normal aortic endothelial cell morphology and significantly reducing biomarkers of vascular injury.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: