Warfarin therapy can rarely cause hemorrhagic skin infarction, a complication that clinicians should be aware of.
An elderly female with congestive heart failure developed a hemorrhagic infarction of the skin of the thigh on the third day following anticoagulation with sodium warfarin. This is an infrequently reported complication of coumarin congener therapy. The case is reported and current concepts concerning pathogenesis and treatment are reviewed. A characteristic lesion is illustrated.
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E. Dale Everett (1969) studied this question.
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