Why the study?
Does amlodipine inhibit serum-, thrombin-, or bFGF-induced proliferation in rat aortic vascular smooth-muscle cells?
Population
Rat aortic vascular smooth-muscle cells (VSMCs) in culture
Comparison
Amlodipine (0.1-10 microM) vs Control, nifedipine, and Bay K 8644
Design
Preclinical
Authors
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Should not change clinical practice; hypothesis-generating for amlodipine's anti-atherosclerotic effects in animal VSMCs.
Does amlodipine inhibit serum-, thrombin-, or bFGF-induced proliferation in rat aortic vascular smooth-muscle cells?
Amlodipine inhibits vascular smooth muscle cell proliferation and DNA synthesis early in the G1 phase, suggesting a potential mechanism for its anti-atherosclerotic effects independent of L-type calcium channel blockade.
Stepien et al. (1998) studied this question.