December 1, 1999AJP Lung Cellular and Molecular Physiology
Inhaled NO reaches distal vasculatures to inhibit endothelium- but not leukocyte-dependent cell adhesion
Why the study?
Does inhaled NO reduce leukocyte adhesion in peripheral microvessels in feline models?
Population
Feline mesentery models subjected to local microvascular changes induced by hydrogen peroxide, histamine, or…
Comparison
Inhaled nitric oxide (NO) at 80 parts/million vs Without NO inhalation
Design
Preclinical
Authors
Discussion
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Implication
Inhaled NO effects unproven in humans; extends evidence for stimulus-specific modulation of leukocyte adhesion in animal microvasculature.
Structured PICO
Does inhaled NO reduce leukocyte adhesion in peripheral microvessels in feline models?
P
Population
Feline mesentery models (cats) subjected to local microvascular changes induced by hydrogen peroxide (H2O2), histamine, or leukotriene B4
I
Intervention
Inhaled nitric oxide (NO) at 80 parts/million
C
Comparator
Without NO inhalation
O
Outcome
Leukocyte rolling and adhesion in the mesenteric microcirculationsurrogate
Inhaled NO can reach the distal microvasculature to inhibit endothelium-dependent, but not leukocyte-dependent, cell adhesion.
Cite This Study
Fox‐Robichaud et al. (1999) studied this question.