Role of nitric oxide in leukotriene C4-induced increases in microvascular transport

View Full Paper

Ask AI

Bookmark

Population

Hamster cheek pouch model in vivo

Comparison

Leukotriene C4 combined with nitric oxide… vs Leukotriene C4 alone, or combined with D-NMMA…

Design

Preclinical

Authors

Discussion

Animal data implicate NO/guanylate cyclase in LTC4 permeability; leaves open relevance to human microvascular leak.

Population

Hamster cheek pouch model in vivo

Intervention

Leukotriene C4 (1.0 and 3.0 nM) combined with nitric oxide inhibitor L-NMMA (1.0 microM) or guanylate cyclase inhibitor LY-83583 (10 microM)

Comparator

Leukotriene C4 alone, or combined with D-NMMA (1.0 microM), indomethacin (10 mg/kg iv), or diphenhydramine hydrochloride (15-20 mg/kg iv)

Outcome

Increases in transport of macromolecules (quantitated by formation of venular leaky sites and clearance of FITC-dextran-70K)surrogate

Nitric oxide production and subsequent guanylate cyclase activation play an important role in leukotriene C4-induced microvascular permeability.

William G. Mayhan (1993) studied this question.

View Full Paper

Ask AI

Bookmark