Why the study?
Does poliovirus vaccination affect secretory IgA antibodies to poliovirus in the milk of lactating women?
Population
Lactating women from Pakistan and Sweden
Comparison
Subcutaneous killed poliovirus vaccine, peroral… vs Pre-vaccination baseline
Design
Other
Follow-up
14 days
Authors
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May reduce secretory IgA in milk of exposed lactating women; leaves open effects on infant protection and vaccination strategies.
Does poliovirus vaccination affect secretory IgA antibodies to poliovirus in the milk of lactating women?
Peroral live poliovirus vaccination may paradoxically decrease existing mucosal immunity (secretory IgA in milk) in previously exposed populations, especially when co-administered with other vaccines.
Svennerholm et al. (1981) studied this question.
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