December 1, 1991Acta Paediatrica

Specific Antibodies to Poliovirus Type I in Breastmilk of Unvaccinated Mothers before and Seven Years after Start of Community‐Wide Vaccination of Their Infants with Live, Oral Poliovirus Vaccine

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Why the study?

Does community-wide vaccination of infants with OPV affect poliovirus type 1 SIgA antibody titers in the breastmilk of unvaccinated mothers?

Structured PICO

Does community-wide vaccination of infants with OPV affect poliovirus type 1 SIgA antibody titers in the breastmilk of unvaccinated mothers?

Population

100 young, healthy, unvaccinated mothers living in urban slum areas of Lahore, Pakistan

Intervention

Community-wide vaccination of their infants with live, oral poliovirus vaccine (OPV)

Comparator

Before vaccination program (1980-1981)

Outcome

Secretory IgA (SIgA) antibodies against poliovirus type 1 in breastmilksurrogate

Breastmilk IgA antibody titers to poliovirus type 1 in unvaccinated mothers reflect seasonal epidemiological conditions rather than infant OPV vaccination, and high colostrum neutralization capacity might interfere with OPV given at birth.

Discussion

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Implication

Maternal breastmilk SIgA tracks community epidemiology, not infant OPV; leaves open potential interference with birth-dose vaccination.

Cite This Study

Zaman et al. (1991) studied this question.

synapsesocial.com/papers/6a8c336fcc5fa73295d48ac7 https://doi.org/10.1111/j.1651-2227.1991.tb11806.x

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