Why the study?
Do calcium channel blockers cause adverse effects such as increased mortality or myocardial infarction in patients with hypertension?
Population
Patients with hypertension
Design
Review
Authors
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Short-acting nifedipine warrants caution in hypertension; this review leaves open optimal long-acting CCB selection pending randomized data.
Do calcium channel blockers cause adverse effects such as increased mortality or myocardial infarction in patients with hypertension?
Short-acting nifedipine is associated with adverse safety signals including increased mortality, whereas long-acting and non-dihydropyridine calcium channel blockers are safer and preferred for specific hypertensive populations.
Lionel H. Opie (1997) studied this question.