January 1, 1991Medical and Pediatric Oncology
Vascular events in patients receiving high‐dose infusional 5‐fluorouracil‐based chemotherapy: The University of Chicago experience
Why the study?
Does infusional 5-fluorouracil-based chemotherapy cause thrombotic vascular events in patients with head and neck or gastrointestinal cancer?
Population
244 patients with head and neck or gastrointestinal cancer
Design
Cohort
Follow-up
up to several months following completion of therapy
Authors
Discussion
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Member takes
Implication
Supports monitoring for thrombosis with infusional 5-FU; hypothesis-generating for causality in head/neck or GI cancers.
Structured PICO
Does infusional 5-fluorouracil-based chemotherapy cause thrombotic vascular events in patients with head and neck or gastrointestinal cancer?
P
Population
244 patients with head and neck or gastrointestinal cancer
I
Intervention
Infusional 5-fluorouracil (5-FU)-based chemotherapy regimens
O
Outcome
Thrombotic vascular events (cardiac arrhythmias, myocardial infarction, sudden death, and thromboembolism)safety
Infusional 5-fluorouracil-based chemotherapy is associated with a 9% incidence of potentially severe thrombotic vascular events.
Cite This Study
Gradishar et al. (1991) studied this question.