Why the study?
5-Fluorouracil-associated cardiotoxicity is a significant yet underrecognized complication of chemotherapy that can necessitate treatment modification or discontinuation.
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5-FU-associated cardiotoxicity is a critical complication requiring prompt recognition, immediate discontinuation of the drug, and multidisciplinary cardio-oncology management.
5-Fluorouracil (5-FU)–associated cardiotoxicity is a significant yet often underrecognized complication of chemotherapy, particularly in patients with gastrointestinal, breast, and head and neck cancers. It presents a range of cardiovascular manifestations—including coronary vasospasm, arrhythmias, myocardial infarction, myocarditis, and heart failure—that can necessitate treatment modification or discontinuation. This review outlines the incidence, clinical manifestations, pathophysiological mechanisms, and current management strategies for 5-FU-induced cardiotoxicity while highlighting future directions for improving risk stratification and therapeutic approaches.
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Hassan Awais (2025) studied this question.
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