Why the study?
Does smoking reduce cardiac mortality in patients receiving thrombolysis for first acute myocardial infarction?
Population
185 consecutive patients receiving thrombolysis for first acute myocardial infarction
Comparison
Smoking (current or previous) vs Non-smokers (never smoked)
Design
Cohort
Follow-up
36 days
Authors
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Does not support smoking to lower AMI mortality; leaves open confounding versus fibrinolysis effects.
Does smoking reduce cardiac mortality in patients receiving thrombolysis for first acute myocardial infarction?
The observed lower short-term cardiac mortality in smokers following thrombolysis for AMI may be related to enhanced systemic fibrinolysis, as the survival benefit was attenuated after adjusting for post-thrombolysis fibrinogen levels.
Ian Purcell (1999) studied this question.
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