Why the study?
Does smoking improve reperfusion and clinical outcomes in acute ischemic stroke patients treated with intravenous tissue plasminogen activator?
Population
148 consecutive acute ischemic stroke patients who had magnetic resonance imaging before and 1 day after…
Comparison
Smoking (active smokers, n=32) vs Non-smokers
Design
Cohort
Follow-up
3 months
Authors
Loading...
Smoking-reperfusion association in this cohort is hypothesis-generating; should not change tPA practice pending confirmation.
Does smoking improve reperfusion and clinical outcomes in acute ischemic stroke patients treated with intravenous tissue plasminogen activator?
Smoking is independently associated with higher rates of recanalization and reperfusion in acute ischemic stroke patients treated with intravenous tPA, suggesting a smoking-thrombolysis paradox similar to that seen in myocardial infarction.
Kufner et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: