Key result
Ever-smoking was associated with a higher rate of complete recanalization after intra-arterial rt-PA for acute ischemic stroke compared to nonsmoking (OR 2.51; 95% CI 1.26-4.99; p=0.009).
Why the study?
Does smoking status improve complete recanalization in acute ischemic stroke patients treated with IA rt-PA?
Cohort (n=227)
Does smoking status improve complete recanalization in acute ischemic stroke patients treated with IA rt-PA?
Odds Ratio: 2.51 (95% CI 1.26–4.99)
p-value: p=0.009
Current and former smokers with acute ischemic stroke treated with IA rt-PA have higher rates of complete arterial recanalization compared to nonsmokers, though this did not translate to improved 90-day clinical outcomes.
No takes yet. Share an insight, caveat, or question.
No change to IA rt-PA protocols by smoking status; observational link leaves open confirmation in prospective trials.
Meseguer et al. (2014) conducted a cohort in Acute ischemic stroke (n=227). Ever-smoking (current or former) vs. Nonsmokers was evaluated on Complete recanalization achieved immediately after termination of IA rt-PA infusion (OR 2.51, 95% CI 1.26-4.99, p=0.009). Ever-smoking was associated with a higher rate of complete recanalization after intra-arterial rt-PA for acute ischemic stroke compared to nonsmoking (OR 2.51; 95% CI 1.26-4.99; p=0.009).
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