Why the study?
Is statin use associated with reduced delirium in critically ill patients with acute respiratory failure or shock?
Is statin use associated with reduced delirium in critically ill patients with acute respiratory failure or shock?
In critically ill patients, continuation or initiation of statins in the ICU is associated with reduced delirium, particularly early in sepsis, whereas discontinuation of prior statin therapy increases delirium risk.
Authors
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May support statin continuation in early sepsis; hypothesis-generating and requires RCTs before practice change.
Morandi et al. (2014) studied this question.
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